Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to the challenge of experimentation in high-containment and outbreak settings. Here, we used single-cell transcriptomics and CyTOF-based single-cell protein quantification to characterize peripheral immune cells during EBOV infection in rhesus monkeys. We obtained 100,000 transcriptomes and 15,000,000 protein profiles, finding that immature, proliferative monocyte-lineage cells with reduced antigen-presentation capacity replace conventional monocyte subsets, while lymphocytes upregulate apoptosis genes and decline in abundance.

By quantifying intracellular viral RNA, we identify molecular determinants of tropism among circulating immune cells and examine temporal dynamics in viral and host gene expression. Within infected cells, EBOV downregulates STAT1 mRNA and interferon signaling, and it upregulates putative pro-viral genes (e.g., DYNLL1 and HSPA5), nominating pathways the virus manipulates for its replication. This study sheds light on EBOV tropism, replication dynamics, and elicited immune response and provides a framework for characterizing host-virus interactions under maximum containment. Dengue virus (DENV) infection is one of the most important infectious diseases in tropical and subtropical regions around the world.

Previously, we performed an initial phenotypic screening of 7,000 compounds using DENV type 2 (DENV2)-infected BHK-21 cells to identify small molecules which could inhibit virus replication. In this study, we describe two novel compounds with anti-DENV2 activity, tentatively named Compound-X and Compound-Y. Both compounds possess a quinolone skeleton, and the EC50s of Compound-X and Compound-Y against DENV2 were 3.9 μM and 9.2 μM, respectively.

Based on a DENV replicon assay, it was suggested that these compounds have anti-DENV2 activity by inhibition of a step in virus replication. Furthermore, using mutational analysis we obtained compounds-resistant to DENV2 infection and identified a mutation, V130A in the NS5 methyltransferase (MTase) domain.

However, these compounds did not inhibit MTase activity. In addition, incorporation of an additional NS1 N246D mutation with the NS5 V130A mutation in DENV2 resulted in recovery of viral replication and a further reduction of the sensitivity to the quinolone compounds by an unknown mechanism. Therefore further investigations are required to clarify the antiviral mechanisms of these quinolone compounds.

Evidence for interspecies transmission route of pseudorabies virus via virally contaminated fomites

Pseudorabies virus (PRV) is a zoonotic agent with a wide host range, causing significant economic losses in animal husbandry and potential public health risk globally. The causative agent has recently gained attention due to the inter-species transmission among different species of animals, even human beings.
Although PRV’s prevalence is found in many species of animals, regardless of whether the strain involved is a vaccine, classical or variant, few lines of evidence for the viral transmission route are available. Here, we reported that viral contamination is associated with the inter-species transmission of PRV.
We found that PRV contamination was widely distributed in the environment of pig farms, that viral distribution in the environment is associated with the implementation of biosecurity measures, and that PRV could transmit from pigs to dogs through virally contaminated fomites. Collectively, our findings provide a basis for understanding the ecology and transmission route of PRV and underscore the importance of implementing biosecurity measures to control this disease.
 Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics
Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Contemporary Understanding of Ebola and Zika Virus in Pregnancy

Understanding the pathophysiology, management, and prevention of emerging infectious diseases among pregnant women is imperative to achieve a successful response from the medical community. Ebola and Zika viruses represent infections with profound public health implications.
In particular, Ebola virus is associated with high case fatality and pregnancy and neonatal loss rates, while Zika virus has been associated with multiple congenital anomalies; these features present critical clinical dilemmas for management of pregnant and reproductive aged women. Influenza B viruses cause significant morbidity and mortality, particularly in children, but the awareness of their impact is often less than influenza A viruses partly due to their lack of pandemic potential. Here, we summarise the biology, epidemiology and disease burden of influenza B, and review existing data on available antivirals for its management.
There has long been uncertainty surrounding the clinical efficacy of neuraminidase inhibitors (NAIs) for influenza B treatment. In this article, we bring together the existing data on NAIs and discuss these alongside recent large randomised controlled trial data for the new polymerase inhibitor baloxavir in high-risk influenza B patients. Finally, we offer considerations for the clinical management of influenza B, with a focus on children and high-risk patients where disease burden is highest.
LIMITED QTY-Dinucleotide Standards Formamido Thymine Dimer d (PfpT) (50 µg)
0801212 50 µg
EUR 118.64
  • What is the product classification?
  • LIMITED QTY-Dinucleotide Standards Formamido Thymine Dimer d PfpT) is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
LIMITED QTY-Dinucleotide Standards Formamido Adenine Dimer d (PfpA) (50 µg)
0801213 50 µg
EUR 118.64
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  • LIMITED QTY-Dinucleotide Standards Formamido Adenine Dimer d PfpA) is marked as RUO.
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LIMITED QTY-Dinucleotide Standards Thymine Glycol Cytidine Dimer d (TgpC) (50µg)
0801216 50µg
EUR 118.64
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Bovine 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080b 96 Tests
EUR 928
Chicken 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080c 96 Tests
EUR 928
Canine 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080d 96 Tests
EUR 928
General 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080Ge 96 Tests
EUR 886
Human 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080h 96 Tests
EUR 824
Mouse 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080m 96 Tests
EUR 865
Porcine 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080p 96 Tests
EUR 928
Rat 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080r 96 Tests
EUR 886
Rabbit 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit
CELI-66080Rb 96 Tests
EUR 928
LIMITED QTY-Dinucleotide Standards Thymine Glycol Guanine Dimer d (TgpG) (50 µg)
0801214 50 µg
EUR 118.64
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  • LIMITED QTY-Dinucleotide Standards Thymine Glycol Guanine Dimer d TgpG) is marked as RUO.
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LIMITED QTY-Dinucleotide Standards Thymine Glycol Thymine Dimer d (TgpT) (50 µg)
0801215 50 µg
EUR 118.64
  • What is the product classification?
  • LIMITED QTY-Dinucleotide Standards Thymine Glycol Thymine Dimer d TgpT) is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
LIMITED QTY-Dinucleotide Standards Thymine Glycol Adenine Dimer d (TgpA) (50 µg)
0801217 50 µg
EUR 118.64
  • What is the product classification?
  • LIMITED QTY-Dinucleotide Standards Thymine Glycol Adenine Dimer d TgpA) is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
LIMITED QTY-rhIL-2 Recombinant Human Interleukin-2 (100 µg)
0802001 100 µg
EUR 362
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  • LIMITED QTY-rhIL-2 Recombinant Human Interleukin-2 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
8-Oxo-GTP
B8045-.01 10 ?l (100 mM)
EUR 105
8-Oxo-GTP
B8045-.05 50 ?l (100 mM)
EUR 313
8-Oxo-GTP
B8045-.1 100 ?l (100 mM)
EUR 479
1730 8 SNAP-SEAL 8 OZ
1730-8 100/pk
EUR 74
Description: Disposable Plastic; Plastic Containers
pCX- DG
PVT11179 2 ug
EUR 337
Individual Reaction Mix 8
G065-8 200 reactions
EUR 167
8-Oxo-DGTP Diphosphatase (mutT) Antibody
20-abx300694
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Human IL-8 Recombinant Protein
R00423-8 5ug/vial
EUR 259
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Human IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.
EXOCET Standards
EXOCET-SD-1
EUR 202
6-Thio-dG
B6009-10 10 mg
EUR 189
Description: 6-thio-dG is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. It is an anti-cancer inhibitor [1]. Cancer cells were very sensitive to 6-thio-dG with observed IC50 values ranging from 0.43283.9 ?M, depending on cell types [3].
6-Thio-dG
B6009-25 25 mg
EUR 380
Description: 6-thio-dG is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. It is an anti-cancer inhibitor [1]. Cancer cells were very sensitive to 6-thio-dG with observed IC50 values ranging from 0.43283.9 ?M, depending on cell types [3].
6-Thio-dG
B6009-5 5 mg
EUR 154
Description: 6-thio-dG is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. It is an anti-cancer inhibitor [1]. Cancer cells were very sensitive to 6-thio-dG with observed IC50 values ranging from 0.43283.9 ?M, depending on cell types [3].
DG-172 (hydrochloride)
C5712-10 10 mg
EUR 231
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.
DG-172 (hydrochloride)
C5712-100 100 mg
EUR 1262
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.
DG-172 (hydrochloride)
C5712-5 5 mg
EUR 158
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.
DG-172 (hydrochloride)
C5712-5.1 10 mM (in 1mL DMSO)
EUR 168
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.
DG-172 (hydrochloride)
C5712-50 50 mg
EUR 756
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.
Escherichia coli 8-oxo-dGTP diphosphatase (mutT)
1-CSB-EP357355ENV
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 30.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Escherichia coli 8-oxo-dGTP diphosphatase(mutT) expressed in E.coli
Escherichia coli 8-oxo-dGTP diphosphatase (mutT)
1-CSB-YP357355ENV
  • EUR 679.00
  • EUR 335.00
  • EUR 2172.00
  • EUR 1051.00
  • EUR 1442.00
  • EUR 435.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 16.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Escherichia coli 8-oxo-dGTP diphosphatase(mutT) expressed in Yeast
8-Oxo-dGTP Diphosphatase (MUTT) Antibody (HRP)
20-abx300695
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
8-Oxo-dGTP Diphosphatase (MUTT) Antibody (FITC)
20-abx300696
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
8-Oxo-dGTP Diphosphatase (MUTT) Antibody (Biotin)
20-abx300697
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Lyophilized Exosome Standards
ExoA375 100 μg
EUR 303.5
Lyophilized Exosome Standards
ExoHT29 100 μg
EUR 303.5
Lyophilized Exosome Standards
ExoMCF7 100 μg
EUR 303.5
Lyophilized Exosome Standards
ExoPC3 100 μg
EUR 303.5
Lyophilized Exosome Standards
ExoPLASMA 100 μg
EUR 303.5
Lyophilized Exosome Standards
ExoUrine 100 μg
EUR 303.5
General 8OHDG/ 8-Oxo-2'-deoxyguanosine ELISA Kit
E0081Ge 1 Kit
EUR 717
General 8- Oxo- 2'- deoxyguanosine, 8OHDG ELISA KIT
ELI-02314Ge 96 Tests
EUR 886
Nucleoside Phosphorylase (Nucleoside phosphorylase) Antibody
abx235893-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.
8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
DLR-8-OHdG-Ge-48T 48T
EUR 469
  • Should the 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.
8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
DLR-8-OHdG-Ge-96T 96T
EUR 608
  • Should the 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.
0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR
AP-8-10 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
20-200UL 8-CHANNEL, DIGITAL PIPETTOR
AP-8-200 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
50-300UL 8-CHANNEL, DIGITAL PIPETTOR
AP-8-300 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
5-50UL 8-CHANNEL, DIGITAL PIPETTOR
AP-8-50 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
3-oxo-8-tbutylcarbonyldicyclo-2-decane-7-boronic ester
abx181986-1g 1 g
EUR 2207
  • Shipped within 1-2 weeks.
General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RD-8-OHdG-Ge-48Tests 48 Tests
EUR 467
General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RD-8-OHdG-Ge-96Tests 96 Tests
EUR 646
General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RDR-8-OHdG-Ge-48Tests 48 Tests
EUR 488
General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit
RDR-8-OHdG-Ge-96Tests 96 Tests
EUR 676
pAAV-DJ/8 Vector
VPK-420-DJ-8 10 µg
EUR 647
Description: The pAAV-DJ/8 vector contains the rep and cap genes required to generated recombinant AAV of serotype DJ/8. Co-transfect with other packaging plasmids and an expression vector into 293 cells for AAV-DJ/8 packaging.
MRC5 Standards A-F
F373 1 ml
EUR 488
  • Product category: Quality control/standard for molecular biology applications
Description: MRC5 Standards A-F by Cygnus Technologies is available in Europe via Gentaur.
tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
20-abx180883
  • EUR 467.00
  • EUR 634.00
  • 250 mg
  • 500 mg
  • Shipped within 1-2 weeks.
10-Oxo Docetaxel
HY-16674 10mg
EUR 2307
Dimethyl(oxo)phosphanium
TBW01428 unit Ask for price
PSA (Prostate-specific antigen) ELISA test
8 96T/Box Ask for price
  • Area of application: Hormone testing
Description: ELISA based test for quantitative detection of PSA (Prostate-specific antigen)
SuperPower (TM) Stain Tablet, Fast Staining Coomassie G-250
DG-STAIN 5drytablets, 5prep
EUR 160.2
  • Product category: Molecular Biology Kits/Protein - Staining
SuperBlot Western Transfer buffer 10X
DG-WEST 500ml
EUR 113.8
  • Product category: Biochemicals/Biological Buffers/Protein Related
E.coli DNA Standards A-H
D413 1 ml
EUR 322
  • Product category: Quality control/standard for molecular biology applications
Description: E.coli DNA Standards A-H by Cygnus Technologies is available in Europe via Gentaur.
CHO DNA Standards (A-H)
D553 1 ml
EUR 322
  • Product category: Quality control/standard for molecular biology applications
Description: CHO DNA Standards (A-H) by Cygnus Technologies is available in Europe via Gentaur.
BSA Standards Set, A-E
F031 1 ml
EUR 403
  • Product category: Quality control/standard for molecular biology applications
Description: BSA Standards Set, A-E by Cygnus Technologies is available in Europe via Gentaur.
Insulin Standards Set, A-G
F043 1 ml
EUR 488
  • Product category: Quality control/standard for molecular biology applications
Description: Insulin Standards Set, A-G by Cygnus Technologies is available in Europe via Gentaur.
HSA Standards Set, A-E
F057 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: HSA Standards Set, A-E by Cygnus Technologies is available in Europe via Gentaur.
S.cerevisiae Standards Set, A-F
F138 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: S.cerevisiae Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Human IgM Standards A-F
F171 1 ml
EUR 488
  • Product category: Quality control/standard for molecular biology applications
Description: Human IgM Standards A-F by Cygnus Technologies is available in Europe via Gentaur.
A549 Standards Set, A-F
F233 1 ml
EUR 450
  • Product category: Quality control/standard for molecular biology applications
Description: A549 Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Protein A Standards A-H
F743 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Protein A Standards A-H by Cygnus Technologies is available in Europe via Gentaur.
Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-100ug
QP7301-ec-100ug 100ug
EUR 707
Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-10ug
QP7301-ec-10ug 10ug
EUR 326
Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-1mg
QP7301-ec-1mg 1mg
EUR 2303
Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-200ug
QP7301-ec-200ug 200ug
EUR 1115
Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-500ug
QP7301-ec-500ug 500ug
EUR 1514
Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-50ug
QP7301-ec-50ug 50ug
EUR 435
Nucleoside-Analog-1
HY-77651 100mg
EUR 2943
Nucleoside-Analog-2
HY-77652 100mg
EUR 2943
Cordycepin (Nucleoside Antagonist)
SIH-576-10MG 10 mg
EUR 126
  • Cordycepin is a neucleoside antagonist that is able to interfere with RNA synthesis (1). Cordyceps have more than 21 clinically approved benefits such as anti-diabetic, anti-tumor, anti-oxidative, immunomodulatory and anti-aging effects (2,3).
Description: The substance Cordycepin is a nucleoside antagonist. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (25 mg/ml).
Cordycepin (Nucleoside Antagonist)
SIH-576-50MG 50 mg
EUR 277
  • Cordycepin is a neucleoside antagonist that is able to interfere with RNA synthesis (1). Cordyceps have more than 21 clinically approved benefits such as anti-diabetic, anti-tumor, anti-oxidative, immunomodulatory and anti-aging effects (2,3).
Description: The substance Cordycepin is a nucleoside antagonist. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (25 mg/ml).
anti-Nucleoside phosphorylase
YF-PA24262 50 ul
EUR 334
Description: Mouse polyclonal to Nucleoside phosphorylase
AAV-DJ/8 Helper Free Packaging System
VPK-400-DJ-8 1 kit
EUR 972
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).
AAV-DJ/8 Helper Free Expression System
VPK-410-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
scAAV-DJ/8 Helper Free Expression System
VPK-430-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
AccuClear Ultra High Sensitivity dsDNA Quantitation Kit with 8 DNA Standards (1000 assays)
31028 1kit
EUR 362
Description: Minimum order quantity: 1 unit of 1kit
AAV-DJ/8 Helper Free Promoterless Expression System
VPK-411-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
Human diacyl glycerol,DAG/DG ELISA kit
201-12-0699 96 tests
EUR 440
  • This diacyl glycerol ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
3?-dG CPG 1000 A (?10 grams)
AHP-CH-DGCPG10 per gram Ask for price
    • Product line: Standard DNA Synthesis CPG
    • Brand:
Human diacyl glycerol(DAG/DG)ELISA Kit
GA-E0715HM-48T 48T
EUR 289
Human diacyl glycerol(DAG/DG)ELISA Kit
GA-E0715HM-96T 96T
EUR 466
Mouse diacyl glycerol(DAG/DG)ELISA Kit
GA-E0350MS-48T 48T
EUR 336
Mouse diacyl glycerol(DAG/DG)ELISA Kit
GA-E0350MS-96T 96T
EUR 534
Human diacyl glycerol(DAG/DG)ELISA Kit
QY-E03682 96T
EUR 400
3β,7β,15β-trihydroxy-11-oxo-lanosta-8-en-24→20 lactone
TBW00249 5mg
EUR 420
General 8-Epi Prostaglandin F2 Alpha (8-epi-PGF2a) ELISA Kit
RD-8-epi-PGF2a-Ge-48Tests 48 Tests
EUR 467
General 8-Epi Prostaglandin F2 Alpha (8-epi-PGF2a) ELISA Kit
RD-8-epi-PGF2a-Ge-96Tests 96 Tests
EUR 646
Ethyl 2-oxo-cycloheptanecarboxylate
20-abx181277
  • EUR 509.00
  • EUR 3195.00
  • EUR 1177.00
  • 1 g
  • 25 g
  • 5 g
  • Shipped within 1-2 weeks.
4-Oxo-2,2,6,6-tetramethylpiperidinooxy
abx183641-250g 250 g
EUR 439
  • Shipped within 1-2 weeks.
11-oxo-mogroside V
HY-N0501 5mg
EUR 380
11-oxo-mogroside V
N2145-20 20 mg
EUR 340
Description: Extracted from Momordica grosvenori Swingle dried ripe fruit ;Store the product in sealed, cool and dry condition
11-oxo-mogroside V
TB0712 20mg
EUR 441
11-oxo-morgroside VI
TBW00882 1mg Ask for price
15-Oxo-cucurbitacin F
TBZ1759 unit Ask for price
1-Oxo-7α-hydroxysitosterol
TBZ1763 unit Ask for price
NS/0 DNA Standards (A-H)
D223 1 ml
EUR 322
  • Product category: Quality control/standard for molecular biology applications
Description: NS/0 DNA Standards (A-H) by Cygnus Technologies is available in Europe via Gentaur.
Library Quantification DNA Standards (S1-S6)
20-abx098897
  • EUR 620.00
  • EUR 620.00
  • EUR 620.00
  • EUR 620.00
  • 25%, 120 ul
  • 37.5%, 120 ul
  • 50%, 120 ul
  • 62.5%, 120 ul
  • Shipped within 5-10 working days.
CHO HCP Standards Set, A-F
F018 1.5 ml
EUR 373
  • Product category: Quality control/standard for molecular biology applications
Description: CHO HCP Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Protein A Standards Set, A-E
F053 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Protein A Standards Set, A-E by Cygnus Technologies is available in Europe via Gentaur.
Mouse IgG1 Standards Set, A-F
F077 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Mouse IgG1 Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Mouse IgG2a Standards Set, A-F
F078 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Mouse IgG2a Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Mouse IgG2b Standards Set, A-F
F079 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Mouse IgG2b Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Mouse IgG Standards Set, A-E
F081 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Mouse IgG Standards Set, A-E by Cygnus Technologies is available in Europe via Gentaur.
Mouse IgM Standards Set, A-F
F093 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Mouse IgM Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Goat IgG Standards Set, A-F
F213 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Goat IgG Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
NS/0 Standards Set, A-G
F223 1 ml
EUR 488
  • Product category: Quality control/standard for molecular biology applications
Description: NS/0 Standards Set, A-G by Cygnus Technologies is available in Europe via Gentaur.
Insulin-US Standards Set, A-F
F282 1 ml
EUR 488
  • Product category: Quality control/standard for molecular biology applications
Description: Insulin-US Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
Protein A Standards Set, A-G
F403 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Protein A Standards Set, A-G by Cygnus Technologies is available in Europe via Gentaur.
E.coli HCP Standards Set, A-F
F413 1 ml
EUR 488
  • Product category: Quality control/standard for molecular biology applications
Description: E.coli HCP Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
P.fluorescens HCP Standards Set, A-F
F453 1 ml
EUR 450
  • Product category: Quality control/standard for molecular biology applications
Description: P.fluorescens HCP Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.
BHK Cell HCP Standards A-F
F513 1 ml
EUR 527
  • Product category: Quality control/standard for molecular biology applications
Description: BHK Cell HCP Standards A-F by Cygnus Technologies is available in Europe via Gentaur.
SF9 HCP Standards Set, A-H
F843 1 ml
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: SF9 HCP Standards Set, A-H by Cygnus Technologies is available in Europe via Gentaur.
AXYGEN® 8-WELL COMB FOR USE WITH 10 CM GEL BOX, 1.0 MM THICKNESS
HGB10-8-1 1/pk
EUR 59
Description: Lab Equipment; Axygen Branded EQ
AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.0 MM THICKNESS
HGB15-8-1 1/pk
EUR 69
Description: Lab Equipment; Axygen Branded EQ
AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS
HGB15-8-15 1/pk
EUR 69
Description: Lab Equipment; Axygen Branded EQ
AXYGEN® 8-WELL COMB FOR USE WITH 7 CM GEL BOX, 0.75 MM THICKNESS
HGB7-8-075 1/pk
EUR 54
Description: Lab Equipment; Axygen Branded EQ
AXYGEN® 8-WELL COMB FOR USE WITH 7 CM GEL BOX, 1.0 MM THICKNESS
HGB7-8-1 1/pk
EUR 54
Description: Lab Equipment; Axygen Branded EQ
AXYPET 0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4
AP-8-10-ALT 1/pk
EUR 456
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AXYPET 0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10
AP-8-10-STD 1/pk
EUR 507
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4
AP-8-200-ALT 1/pk
EUR 456
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10
AP-8-200-STD 1/pk
EUR 507
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4
AP-8-300-ALT 1/pk
EUR 456
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10
AP-8-300-STD 1/pk
EUR 507
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4
AP-8-50-ALT 1/pk
EUR 456
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10
AP-8-50-STD 1/pk
EUR 507
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller
AAV-DJ/8 Helper Free Bicistronic Expression System (Puro)
VPK-415-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
AAV-DJ/8 Helper Free Bicistronic Expression System (Neo)
VPK-416-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
AAV-DJ/8 Helper Free Bicistronic Expression System (Hygro)
VPK-417-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
AAV-DJ/8 Helper Free Bicistronic Expression System (GFP)
VPK-418-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
AAV-DJ/8 Helper Free Bicistronic Expression System (Blasticidin)
VPK-419-DJ-8 1 kit
EUR 1239
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.
Nucleoside Phosphorylase (NP) Antibody
20-abx131483
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Nucleoside Phosphorylase (NP) Antibody
20-abx131484
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Nucleoside Phosphorylase (NP) Antibody
20-abx131485
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.
Purine Nucleoside Phosphorylase (Recombinant)
20-abx072007
  • EUR 913.00
  • EUR 3585.00
  • EUR 328.00
  • 190 µg
  • 1 mg
  • 40 µg
  • Shipped within 5-10 working days.
Purine Nucleoside Phosphorylase (Recombinant)
20-abx073172
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
anti- Nucleoside phosphorylase antibody
FNab05893 100µg
EUR 505.25
  • Immunogen: nucleoside phosphorylase
  • Uniprot ID: P00491
  • Research Area: Metabolism
Description: Antibody raised against Nucleoside phosphorylase
Anti-Nucleoside phosphorylase antibody
PAab05893 100 ug
EUR 355
Recombinant Nucleoside Phosphorylase (NP)
4-RPC683Hu01
  • EUR 426.14
  • EUR 217.00
  • EUR 1323.04
  • EUR 507.68
  • EUR 915.36
  • EUR 348.00
  • EUR 3157.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P00491
  • Buffer composition: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 35.8kDa
  • Isoelectric Point: 6.5
Description: Recombinant Human Nucleoside Phosphorylase expressed in: E.coli
Recombinant Nucleoside Phosphorylase (NP)
4-RPC683Mu01
  • EUR 453.02
  • EUR 224.00
  • EUR 1423.84
  • EUR 541.28
  • EUR 982.56
  • EUR 366.00
  • EUR 3409.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P23492
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 35.7kDa
  • Isoelectric Point: Inquire
Description: Recombinant Mouse Nucleoside Phosphorylase expressed in: E.coli
Recombinant Nucleoside Phosphorylase (NP)
4-RPC683Ra01
  • EUR 453.02
  • EUR 224.00
  • EUR 1423.84
  • EUR 541.28
  • EUR 982.56
  • EUR 366.00
  • EUR 3409.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P85973
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 36.0kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Nucleoside Phosphorylase expressed in: E.coli
MINI TUBE, 8 STRIP, POLYPROPYLENE, 1.1 ML, CLEAR, NONSTERILE, BULK
MTS-11-8-C 120/pk
EUR 140
Description: Deep Well/Assay Plates - Axygen; Assay/Other - Axygen
3?-dG CPG 1000 A (1-9 grams)
AHP-CH-DGCPG01 per gram Ask for price
    • Product line: Standard DNA Synthesis CPG
    • Brand:
ELISA kit for Rat Diacyl glycerol (DAG/DG)
KTE100797-48T 48T
EUR 354
  • Monoacylglycerol (MAG) and diacylglycerol (DAG) are minor components of edible fats and oils, and they relate to the quality of these foods. The AOCS official method Cd 11b-91 has been used to determine MAG and DAG contents in fats and oils. There
  • Show more
Description: Quantitative sandwich ELISA for measuring Rat Diacyl glycerol (DAG/DG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Rat Diacyl glycerol (DAG/DG)
KTE100797-5platesof96wells 5 plates of 96 wells
EUR 2252
  • Monoacylglycerol (MAG) and diacylglycerol (DAG) are minor components of edible fats and oils, and they relate to the quality of these foods. The AOCS official method Cd 11b-91 has been used to determine MAG and DAG contents in fats and oils. There
  • Show more
Description: Quantitative sandwich ELISA for measuring Rat Diacyl glycerol (DAG/DG) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Using joint species distribution modelling, we attribute the non-random virus occurrence patterns primarily to differences among host genotypes and local population context. Our results show that intraspecific variation among host genotypes may play a large, previously unquantified role in pathogen community structure.

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