Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to the challenge of experimentation in high-containment and outbreak settings. Here, we used single-cell transcriptomics and CyTOF-based single-cell protein quantification to characterize peripheral immune cells during EBOV infection in rhesus monkeys. We obtained 100,000 transcriptomes and 15,000,000 protein profiles, finding that immature, proliferative monocyte-lineage cells with reduced antigen-presentation capacity replace conventional monocyte subsets, while lymphocytes upregulate apoptosis genes and decline in abundance.

By quantifying intracellular viral RNA, we identify molecular determinants of tropism among circulating immune cells and examine temporal dynamics in viral and host gene expression. Within infected cells, EBOV downregulates STAT1 mRNA and interferon signaling, and it upregulates putative pro-viral genes (e.g., DYNLL1 and HSPA5), nominating pathways the virus manipulates for its replication. This study sheds light on EBOV tropism, replication dynamics, and elicited immune response and provides a framework for characterizing host-virus interactions under maximum containment. Dengue virus (DENV) infection is one of the most important infectious diseases in tropical and subtropical regions around the world.

Previously, we performed an initial phenotypic screening of 7,000 compounds using DENV type 2 (DENV2)-infected BHK-21 cells to identify small molecules which could inhibit virus replication. In this study, we describe two novel compounds with anti-DENV2 activity, tentatively named Compound-X and Compound-Y. Both compounds possess a quinolone skeleton, and the EC50s of Compound-X and Compound-Y against DENV2 were 3.9 μM and 9.2 μM, respectively.

Based on a DENV replicon assay, it was suggested that these compounds have anti-DENV2 activity by inhibition of a step in virus replication. Furthermore, using mutational analysis we obtained compounds-resistant to DENV2 infection and identified a mutation, V130A in the NS5 methyltransferase (MTase) domain.

However, these compounds did not inhibit MTase activity. In addition, incorporation of an additional NS1 N246D mutation with the NS5 V130A mutation in DENV2 resulted in recovery of viral replication and a further reduction of the sensitivity to the quinolone compounds by an unknown mechanism. Therefore further investigations are required to clarify the antiviral mechanisms of these quinolone compounds.

Evidence for interspecies transmission route of pseudorabies virus via virally contaminated fomites

Pseudorabies virus (PRV) is a zoonotic agent with a wide host range, causing significant economic losses in animal husbandry and potential public health risk globally. The causative agent has recently gained attention due to the inter-species transmission among different species of animals, even human beings.
Although PRV’s prevalence is found in many species of animals, regardless of whether the strain involved is a vaccine, classical or variant, few lines of evidence for the viral transmission route are available. Here, we reported that viral contamination is associated with the inter-species transmission of PRV.
We found that PRV contamination was widely distributed in the environment of pig farms, that viral distribution in the environment is associated with the implementation of biosecurity measures, and that PRV could transmit from pigs to dogs through virally contaminated fomites. Collectively, our findings provide a basis for understanding the ecology and transmission route of PRV and underscore the importance of implementing biosecurity measures to control this disease.
 Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics
Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Contemporary Understanding of Ebola and Zika Virus in Pregnancy

Understanding the pathophysiology, management, and prevention of emerging infectious diseases among pregnant women is imperative to achieve a successful response from the medical community. Ebola and Zika viruses represent infections with profound public health implications.
In particular, Ebola virus is associated with high case fatality and pregnancy and neonatal loss rates, while Zika virus has been associated with multiple congenital anomalies; these features present critical clinical dilemmas for management of pregnant and reproductive aged women. Influenza B viruses cause significant morbidity and mortality, particularly in children, but the awareness of their impact is often less than influenza A viruses partly due to their lack of pandemic potential. Here, we summarise the biology, epidemiology and disease burden of influenza B, and review existing data on available antivirals for its management.
There has long been uncertainty surrounding the clinical efficacy of neuraminidase inhibitors (NAIs) for influenza B treatment. In this article, we bring together the existing data on NAIs and discuss these alongside recent large randomised controlled trial data for the new polymerase inhibitor baloxavir in high-risk influenza B patients. Finally, we offer considerations for the clinical management of influenza B, with a focus on children and high-risk patients where disease burden is highest.

Porcine 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit

CELI-66080p 96 Tests
EUR 1113.6

Rat 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit

CELI-66080r 96 Tests
EUR 1063.2

Rabbit 8- Oxo- 2'- deoxyguanosine, 8- oxo- Dg ELISA Kit

CELI-66080Rb 96 Tests
EUR 1113.6

LIMITED QTY-Dinucleotide Standards Formamido Guanine Dimer d (PfpG) (50 µg)

0801210 50 µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-Dinucleotide Standards Formamido Cytidine Dimer d (PfpC) (50 µg)

0801211 50 µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-Dinucleotide Standards Formamido Thymine Dimer d (PfpT) (50 µg)

0801212 50 µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-Dinucleotide Standards Formamido Adenine Dimer d (PfpA) (50 µg)

0801213 50 µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-Dinucleotide Standards Thymine Glycol Cytidine Dimer d (TgpC) (50µg)

0801216 50µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-Dinucleotide Standards Thymine Glycol Guanine Dimer d (TgpG) (50 µg)

0801214 50 µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-Dinucleotide Standards Thymine Glycol Thymine Dimer d (TgpT) (50 µg)

0801215 50 µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-Dinucleotide Standards Thymine Glycol Adenine Dimer d (TgpA) (50 µg)

0801217 50 µg
EUR 142.37
Description: Please contact Gentaur in order to receive the datasheet of the product.

LIMITED QTY-rhIL-2 Recombinant Human Interleukin-2 (100 µg)

0802001 100 µg
EUR 434.4
Description: Please contact Gentaur in order to receive the datasheet of the product.

8-Oxo-GTP

B8045-.01 10 ?l (100 mM)
EUR 126

8-Oxo-GTP

B8045-.05 50 ?l (100 mM)
EUR 375.6

8-Oxo-GTP

B8045-.1 100 ?l (100 mM)
EUR 574.8

1730 8 SNAP-SEAL 8 OZ

1730-8 100/pk
EUR 88.8
Description: Disposable Plastic; Plastic Containers

pCX- DG

PVT11179 2 ug
EUR 404.4

PLASTIC LUER VALVE 1/8 NPTM QTY 5

ZF000PLSV EACH
EUR 106.02

Individual Reaction Mix 8

G065-8 200 reactions
EUR 200.4

8-Oxo-DGTP Diphosphatase (mutT) Antibody

20-abx300694
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human IL-8 Recombinant Protein

R00423-8 5ug/vial
EUR 310.8
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Human IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

EXOCET Standards

EXOCET-SD-1
EUR 242.4

DG-172 (hydrochloride)

C5712-10 10 mg
EUR 277.2
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.

DG-172 (hydrochloride)

C5712-100 100 mg
EUR 1514.4
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.

DG-172 (hydrochloride)

C5712-5 5 mg
EUR 189.6
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.

DG-172 (hydrochloride)

C5712-5.1 10 mM (in 1mL DMSO)
EUR 201.6
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.

DG-172 (hydrochloride)

C5712-50 50 mg
EUR 907.2
Description: DG-172 (hydrochloride) is an orally available inverse agonist of PPAR?/? with IC50 value of 27 nM [1]. Peroxisome proliferator-activated receptors (PPARs) are a member of the class II subset of nuclear receptors.

6-Thio-dG

B6009-10 10 mg
EUR 226.8
Description: 6-thio-dG is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. It is an anti-cancer inhibitor [1]. Cancer cells were very sensitive to 6-thio-dG with observed IC50 values ranging from 0.43283.9 ?M, depending on cell types [3].

6-Thio-dG

B6009-25 25 mg
EUR 456
Description: 6-thio-dG is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. It is an anti-cancer inhibitor [1]. Cancer cells were very sensitive to 6-thio-dG with observed IC50 values ranging from 0.43283.9 ?M, depending on cell types [3].

6-Thio-dG

B6009-5 5 mg
EUR 184.8
Description: 6-thio-dG is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. It is an anti-cancer inhibitor [1]. Cancer cells were very sensitive to 6-thio-dG with observed IC50 values ranging from 0.43283.9 ?M, depending on cell types [3].

Escherichia coli 8-oxo-dGTP diphosphatase (mutT)

1-CSB-YP357355ENV
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli 8-oxo-dGTP diphosphatase(mutT) expressed in Yeast

Escherichia coli 8-oxo-dGTP diphosphatase (mutT)

1-CSB-EP357355ENV
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli 8-oxo-dGTP diphosphatase(mutT) expressed in E.coli

8-Oxo-dGTP Diphosphatase (MUTT) Antibody (HRP)

20-abx300695
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

8-Oxo-dGTP Diphosphatase (MUTT) Antibody (FITC)

20-abx300696
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

8-Oxo-dGTP Diphosphatase (MUTT) Antibody (Biotin)

20-abx300697
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Pesticide Mix 8 Containing 15 Compounds in Acetonitrile

SPXPR-8 1ML
EUR 249.66

ROCare B Qty 12

ZWBASE012 EACH
EUR 246.24

ROProtect C Qty 48

ZWCL01F50SIG PK48
EUR 106.02

8 mm Crimp head ; Level 3 High Performance Applications

ECMJ-8 EACH
EUR 295.26

General 8OHDG/ 8-Oxo-2'-deoxyguanosine ELISA Kit

E0081Ge 1 Kit
EUR 860.4

General 8- Oxo- 2'- deoxyguanosine, 8OHDG ELISA KIT

ELI-02314Ge 96 Tests
EUR 1063.2

Lyophilized Exosome Standards

ExoA375 100 μg
EUR 364.2

Lyophilized Exosome Standards

ExoHT29 100 μg
EUR 364.2

Lyophilized Exosome Standards

ExoMCF7 100 μg
EUR 364.2

Lyophilized Exosome Standards

ExoPC3 100 μg
EUR 364.2

Lyophilized Exosome Standards

ExoPLASMA 100 μg
EUR 364.2

Lyophilized Exosome Standards

ExoUrine 100 μg
EUR 364.2

Density Standards 6ml

DEN1012 PK10
EUR 69.31

Chlorine meter standards

WAT1076 EACH
EUR 269.04

Nucleoside Phosphorylase (Nucleoside phosphorylase) Antibody

abx235893-100ug 100 ug
EUR 577.2

Limited Availability - Micrewtube 1.5ml Sterile

RFS035 PK500
EUR 156.18

Limited Availability - Micrewtube Skirted 2.0mL

TUB2218 PK1000
EUR 213.18

PROGARD XL-S QTY 1

PR0GTXL0S1 EACH
EUR 589.38

PROGARD XL-S QTY 2

PR0GTXL0S2 EACH
EUR 1183.32

UF PRETREATMENT CARTRIDGE QTY 2

ZUFPREUF2 EACH
EUR 1386.24

Human THSD7a ELISA kit

8-E01A2155
  • EUR 1524.00
  • EUR 624.00
  • EUR 822.00
  • 192 tests
  • 1 plate of 48 wells
  • 1 plate of 96 wells
Description: A competitive ELISA for quantitative measurement of Human THSD7a in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

DLR-8-OHdG-Ge-48T 48T
EUR 562.8
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

DLR-8-OHdG-Ge-96T 96T
EUR 729.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.

0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-10 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

20-200UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-200 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

50-300UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-300 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

5-50UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-50 1/pk
EUR 510
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

3-oxo-8-tbutylcarbonyldicyclo-2-decane-7-boronic ester

abx181986-1g 1 g
EUR 2648.4

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RDR-8-OHdG-Ge-48Tests 48 Tests
EUR 585.6

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RDR-8-OHdG-Ge-96Tests 96 Tests
EUR 811.2

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RD-8-OHdG-Ge-48Tests 48 Tests
EUR 560.4

General 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

RD-8-OHdG-Ge-96Tests 96 Tests
EUR 775.2

pAAV-DJ/8 Vector

VPK-420-DJ-8 10 µg
EUR 776.4
Description: The pAAV-DJ/8 vector contains the rep and cap genes required to generated recombinant AAV of serotype DJ/8. Co-transfect with other packaging plasmids and an expression vector into 293 cells for AAV-DJ/8 packaging.

Kinesis Mini DG PEEK 100ul

CHR2903 EACH
EUR 347.7

MRC5 Standards A-F

F373 1 ml
EUR 585.6
Description: MRC5 Standards A-F by Cygnus Technologies is available in Europe via Gentaur.

Limited Availability - Simport Micrewtube Skirted 1.5ml

TUB2206 PK1000
EUR 239.4

Limited Availability - Micrewtube 1.5ml With Loop

T3324 PK1000
EUR 256.5

N.8 Nom Kine/Dyna Viscosity Density Std

REVIS-N-8 500ML
EUR 190.38

tert-Butyl 1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate

20-abx180883
  • EUR 560.40
  • EUR 760.80
  • 250 mg
  • 500 mg

Progard XL-S-C Qty 1

PR0GTXLCS1 EACH
EUR 630.42

Progard XL-S-C Qty 2

PR0GTXLCS2 EACH
EUR 1260.84

LUER CAP WITH SEPTUM QTY 5

ZF000LCSV EACH
EUR 90.06

Crystallization Plate Sealing Paddle Qty: 5

M-CTP-PDL1 5 PADDLES
EUR 21
Description: Crystallization Plate Sealing Paddle Qty: 5

SuperPower (TM) Stain Tablet, Fast Staining Coomassie G-250

DG-STAIN 5drytablets, 5prep
EUR 192.24

SuperBlot Western Transfer buffer 10X

DG-WEST 500ml
EUR 136.56

10-Oxo Docetaxel

HY-16674 10mg
EUR 2768.4

Dimethyl(oxo)phosphanium

TBW01428 unit Ask for price

Set of 8 Sulfur Oil Standards in Base Oil 20 100 grams

DSS8-SET EACH
EUR 636.12

PSA (Prostate-specific antigen) ELISA test

8 96T/Box Ask for price
Description: ELISA based test for quantitative detection of PSA (Prostate-specific antigen)

Nucleoside-Analog-1

HY-77651 100mg
EUR 3531.6

Nucleoside-Analog-2

HY-77652 100mg
EUR 3531.6

Cordycepin (Nucleoside Antagonist)

SIH-576-10MG 10 mg
EUR 151.2
Description: The substance Cordycepin is a nucleoside antagonist. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (25 mg/ml).

Cordycepin (Nucleoside Antagonist)

SIH-576-50MG 50 mg
EUR 332.4
Description: The substance Cordycepin is a nucleoside antagonist. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is May be dissolved in DMSO (25 mg/ml).

anti-Nucleoside phosphorylase

YF-PA24262 50 ul
EUR 400.8
Description: Mouse polyclonal to Nucleoside phosphorylase

Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-100ug

QP7301-ec-100ug 100ug
EUR 848.4

Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-10ug

QP7301-ec-10ug 10ug
EUR 391.2

Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-1mg

QP7301-ec-1mg 1mg
EUR 2763.6

Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-200ug

QP7301-ec-200ug 200ug
EUR 1338

Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-500ug

QP7301-ec-500ug 500ug
EUR 1816.8

Recombinant E.coli 8-oxo-dGTP diphosphatase Protein, His-SUMO, E.coli-50ug

QP7301-ec-50ug 50ug
EUR 522

E.coli DNA Standards A-H

D413 1 ml
EUR 386.4
Description: E.coli DNA Standards A-H by Cygnus Technologies is available in Europe via Gentaur.

CHO DNA Standards (A-H)

D553 1 ml
EUR 386.4
Description: CHO DNA Standards (A-H) by Cygnus Technologies is available in Europe via Gentaur.

BSA Standards Set, A-E

F031 1 ml
EUR 483.6
Description: BSA Standards Set, A-E by Cygnus Technologies is available in Europe via Gentaur.

Insulin Standards Set, A-G

F043 1 ml
EUR 585.6
Description: Insulin Standards Set, A-G by Cygnus Technologies is available in Europe via Gentaur.

HSA Standards Set, A-E

F057 1 ml
EUR 493.2
Description: HSA Standards Set, A-E by Cygnus Technologies is available in Europe via Gentaur.

S.cerevisiae Standards Set, A-F

F138 1 ml
EUR 493.2
Description: S.cerevisiae Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.

Human IgM Standards A-F

F171 1 ml
EUR 585.6
Description: Human IgM Standards A-F by Cygnus Technologies is available in Europe via Gentaur.

A549 Standards Set, A-F

F233 1 ml
EUR 540
Description: A549 Standards Set, A-F by Cygnus Technologies is available in Europe via Gentaur.

Protein A Standards A-H

F743 1 ml
EUR 493.2
Description: Protein A Standards A-H by Cygnus Technologies is available in Europe via Gentaur.

Hellma Cuvette Calibration Standards Set

CEL1730 EACH
EUR 2039.46

Hellma(R) liquid calibration standards

Z803251-1EA EACH
EUR 627

MicroCrystal Mount Assortment, box of 20; Model #8, on 18mm rods

M4-L18SP-8 20 MOUNTS
EUR 125
Description: MicroCrystal Mount Assortment, box of 20; Model #8, on 18mm rods

Limited Availability - Simport Cryovial T309 3ml 12.5x70mm

CRY2252 PK1000
EUR 313.5

Limited Availability - Simport Cryovial T309 4ml 12.5x76mm

CRY2254 PK1000
EUR 345.42

Limited Availability Simport Micrewtube Skirted 0.5ml Sterile

TUB2202 PK500
EUR 123.12

Limited Availability - Micrewtube Skirted 2.0mL Strl Prntd

TUB2222 PK500
EUR 185.82

Limited Availability - Micrewtube conical 2.0mL Strl Prntd

TUB2228 PK500
EUR 194.94

AAV-DJ/8 Helper Free Packaging System

VPK-400-DJ-8 1 kit
EUR 1166.4
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1).

AAV-DJ/8 Helper Free Expression System

VPK-410-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

scAAV-DJ/8 Helper Free Expression System

VPK-430-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AccuClear Ultra High Sensitivity dsDNA Quantitation Kit with 8 DNA Standards (1000 assays)

31028 1kit
EUR 434.4
Description: Minimum order quantity: 1 unit of 1kit

Set of 8 Sulfur in Oil Standards in no.2 DieselFuel 100 grams

SDFS-SET EACH
EUR 657.78

AAV-DJ/8 Helper Free Promoterless Expression System

VPK-411-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

Ethyl 2-oxo-cycloheptanecarboxylate

20-abx181277
  • EUR 610.80
  • EUR 3834.00
  • EUR 1412.40
  • 1 g
  • 25 g
  • 5 g

4-Oxo-2,2,6,6-tetramethylpiperidinooxy

abx183641-250g 250 g
EUR 526.8

11-oxo-mogroside V

N2145-20 20 mg
EUR 408
Description: Extracted from Momordica grosvenori Swingle dried ripe fruit ;Store the product in sealed, cool and dry condition

11-oxo-mogroside V

HY-N0501 5mg
EUR 456

11-oxo-mogroside V

TB0712 20mg
EUR 529.2

11-oxo-morgroside VI

TBW00882 1mg Ask for price

15-Oxo-cucurbitacin F

TBZ1759 unit Ask for price

1-Oxo-7α-hydroxysitosterol

TBZ1763 unit Ask for price

3?-dG CPG 1000 A (?10 grams)

AHP-CH-DGCPG10 per gram Ask for price

Mouse diacyl glycerol(DAG/DG)ELISA Kit

GA-E0350MS-48T 48T
EUR 403.2

Mouse diacyl glycerol(DAG/DG)ELISA Kit

GA-E0350MS-96T 96T
EUR 640.8

Human diacyl glycerol,DAG/DG ELISA kit

201-12-0699 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human diacyl glycerol(DAG/DG)ELISA Kit

GA-E0715HM-48T 48T
EUR 346.8

Human diacyl glycerol(DAG/DG)ELISA Kit

GA-E0715HM-96T 96T
EUR 559.2

Human diacyl glycerol(DAG/DG)ELISA Kit

QY-E03682 96T
EUR 480

Kinesis Asy;GPC Mini DG Ch;480uL

CHR2913 EACH
EUR 507.3

3β,7β,15β-trihydroxy-11-oxo-lanosta-8-en-24→20 lactone

TBW00249 5mg
EUR 504

General 8-Epi Prostaglandin F2 Alpha (8-epi-PGF2a) ELISA Kit

RD-8-epi-PGF2a-Ge-48Tests 48 Tests
EUR 560.4

General 8-Epi Prostaglandin F2 Alpha (8-epi-PGF2a) ELISA Kit

RD-8-epi-PGF2a-Ge-96Tests 96 Tests
EUR 775.2

Limited Availability - Simport Micrewtube Skirted 0.5ml Sterile Printed

TUB2204 PK500
EUR 194.94

Limited Availability - Simport Micrewtube Skirted 1.5ml Sterile Printed

TUB2210 PK500
EUR 182.4

Limited Availability - Simport Micrewtube Conical 1.5ml Sterile Printed

TUB2216 PK500
EUR 194.94

Cryo Shutter for Cryojet Systems (Limited Space Configuration)

M-CC-330-19LTD 1 Kit
EUR 1250
Description: Cryo Shutter for Cryojet Systems (Limited Space Configuration)

AXYPET 0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4

AP-8-10-ALT 1/pk
EUR 547.2
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10

AP-8-10-STD 1/pk
EUR 608.4
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4

AP-8-200-ALT 1/pk
EUR 547.2
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 20-200UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10

AP-8-200-STD 1/pk
EUR 608.4
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4

AP-8-300-ALT 1/pk
EUR 547.2
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 50-300UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10

AP-8-300-STD 1/pk
EUR 608.4
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X4

AP-8-50-ALT 1/pk
EUR 547.2
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 5-50UL 8-CHANNEL, DIGITAL PIPETTOR ISO17025 3X10

AP-8-50-STD 1/pk
EUR 608.4
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AAV-DJ/8 Helper Free Bicistronic Expression System (Puro)

VPK-415-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Neo)

VPK-416-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Hygro)

VPK-417-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (GFP)

VPK-418-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

AAV-DJ/8 Helper Free Bicistronic Expression System (Blasticidin)

VPK-419-DJ-8 1 kit
EUR 1486.8
Description: The AAV Helper Free System produces recombinant AAV containing your gene of interest without the need to use a helper adenovirus. The adenoviral genes required for proper AAV packaging are provided in the pHelper plasmid (E2A, E4 and VA RNA) or in the 293 packaging cells (E1). AAV Helper Free Complete Expression Systems are available for native serotypes 1 through 6, as well as the novel AAV-DJ and AAV-DJ/8. The AAV-DJ system provides a hybrid capsid created by DNA shuffling technology combining 8 different native serotypes: AAV-2, AAV-4, AAV-5, AAV-8, AAV-9, avian AAV, bovine AAV, and caprine AAV. The result is a highly infectious vector that can transduce a wide variety of cells and tissues at significantly higher rates than AAV-2. AAV-DJ/8 was created by making a point mutation in the heparin binding domain of AAV-DJ. Recombinant AAV produced from the AAV-DJ/8 system closely resembles AAV-8 and AAV-9 in its ability to infect heart and brain tissues.

IC Multi Elem (8) Cation Std in 0.005% HNO3

IC-LGC-8-100 100ML
EUR 235.98

AXYGEN® 8-WELL COMB FOR USE WITH 10 CM GEL BOX, 1.0 MM THICKNESS

HGB10-8-1 1/pk
EUR 70.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.0 MM THICKNESS

HGB15-8-1 1/pk
EUR 82.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 8-WELL COMB FOR USE WITH 15 CM GEL BOX, 1.5 MM THICKNESS

HGB15-8-15 1/pk
EUR 82.8
Description: Lab Equipment; Axygen Branded EQ
Using joint species distribution modelling, we attribute the non-random virus occurrence patterns primarily to differences among host genotypes and local population context. Our results show that intraspecific variation among host genotypes may play a large, previously unquantified role in pathogen community structure.

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